Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Elzasonan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 14/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 14/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | BID | P55957 | 1/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.42 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Elzasonan SCHEMBL29379325 | 0.98 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| Elzasonan SCHEMBL5159647 | 0.98 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| Elzasonan SCHEMBL5159632 | 0.98 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| Elzasonan SCHEMBL5159337 | 0.98 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| Elzasonan SCHEMBL4604005 | 0.96 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| Elzasonan SCHEMBL4604000 | 0.96 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| Elzasonan SCHEMBL4604009 | 0.96 | SLC6A2 (0.48) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| SCHEMBL5160805 | 0.94 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| SCHEMBL5160797 | 0.94 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 | |
| SCHEMBL5606554 | 0.89 | BCL2A1 (0.44) | SLC6A2SLC6A4SLC6A3HTR1ABCL2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |