SCHEMBL1650681

SCHEMBL1650681

C/C(=C/C(=O)c1ccccc1)N[C@@H](Cc1ccc(OCCc2nc(-c3ccccc3)oc2C)cc1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 19/20 1.00
PPARA Q07869 9/20 1.00
PPARD Q03181 3/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1650684 1.00 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL6604515 1.00 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL27568074 1.00 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL6602393 0.97 PPARG (0.94) PPARGPPARAPPARD
SCHEMBL27568030 0.97 PPARG (0.94) PPARGPPARAPPARD
SCHEMBL6602397 0.97 PPARG (0.94) PPARGPPARAPPARD
SCHEMBL6602380 0.97 PPARG (0.94) PPARGPPARAPPARD
SCHEMBL6603468 0.96 PPARG (0.92) PPARGPPARAPPARD
SCHEMBL6603462 0.96 PPARG (0.92) PPARGPPARAPPARD
SCHEMBL6603450 0.96 PPARG (0.92) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 303 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4483376-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME García Sada, Fernando (MX) 2025-01-01 EP claimed
CN-118922890-A Measurement, diagnosis, treatment and management of metabolic syndrome 费尔南多·加西亚·萨达 2024-11-08 CN claimed
CN-114773930-B Manufacturing method of hand-painted wall painting 南阳理工学院 2024-02-27 CN claimed
WO-2023161832-A1 MEASUREMENT, DIAGNOSIS, TREATMENT AND MANAGEMENT OF METABOLIC SYNDROME GARCIA SADA FERNANDO (MX) 2023-08-31 WO claimed
US-20230266340-A1 Measurement, Diagnosis, Treatment and Management of Metabolic Syndrome SILTI AG (CH) 2023-08-24 US claimed
US-20110092524-A1 Agent for Enhancing Corneal Epithelial Barrier Function SANTEN PHARMACEUTICAL CO., LTD. (JP) 2011-04-21 US claimed
EP-2253325-A1 AGENT FOR ENHANCING CORNEAL EPITHELIAL BARRIER FUNCTION Santen Pharmaceutical Co., Ltd (JP) 2010-11-24 EP claimed
US-20040091407-A1 Novel process for preparing crystalline particles SMITHKLINE BEECHAM CORPORATION 2004-05-13 US claimed
EP-1102757-B1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LTD (GB) 2004-04-14 EP claimed
EP-1294362-A1 NOVEL PROCESS FOR PREPARING CRYSTALLINE PARTICLES GLAXO GROUP LIMITED (GB) 2003-03-26 EP claimed
US-6498174-B1 AGONISTS TO PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; MODULATING BLOOD GLUCOSE AND LIPID LEVELS; REDUCING DYSLIPIDEMIA AND HYPERINSULINEMIA ASSOCIATED WITH IMPAIRED GLUCOSE TOLERANCE OR METABOLIC SYNDROME SMITHKLINE BEECHAM CORPORATION 2002-12-24 US claimed
WO-2002000200-A1 NOVEL PROCESS FOR PREPARING CRYSTALLINE PARTICLES GLAXO GROUP LIMITED (GB) 2002-01-03 WO claimed
CN-1321152-A Substituted oxazole and thiazole derivatives as hPPAR gamma and hPPAR alpha activators GLAXO GROUP LTD (GB) 2001-11-07 CN claimed
WO-2001057001-A1 OXAZOLETHOXYPHENYLPROPANOIC ACID DERIVATIVE AS NIDDM- MEDICAMENT GLAXO GROUP LIMITED (GB) 2001-08-09 WO claimed
EP-4744669-A2 APOLIPOPROTEIN C3 (APOC3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF Alnylam Pharmaceuticals, Inc. (US) 2026-05-20 EP disclosed
EP-3823631-B1 METHODS OF TREATING HFPEF EMPLOYING DAPAGLIFLOZIN AND COMPOSITIONS COMPRISING THE SAME ASTRAZENECA AB (SE) 2026-05-20 EP disclosed
US-20260132164-A1 PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF MERCK SHARP & DOHME LLC (US) 2026-05-14 US disclosed
WO-2001057001-A1 OXAZOLETHOXYPHENYLPROPANOIC ACID DERIVATIVE AS NIDDM- MEDICAMENT GLAXO GROUP LIMITED (GB) 2001-08-09 WO disclosed
EP-1102757-A1 SUBSTITUTED OXAZOLE AND THIAZOLE DERIVATIVES AS HPPAR GAMMA AND HPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2001-05-30 EP disclosed
WO-2000008002-A1 SUBSTITUTED OXAZOLES AND THIAZOLES DERIVATIVES AS hPPAR GAMMA AND hPPAR ALPHA ACTIVATORS GLAXO GROUP LIMITED (GB) 2000-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260132164-A1 PNU ANTHRACYCLINE DERIVATIVES AND METHODS OF USE THEREOF TOP1, NCL, NOLC1 PPARG 3339/4885PPARA 2387/4885PPARD 3056/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.