Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 16/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479003 | 0.86 | RAF1 (0.48) | RAF1BRAFKDR | |
| SCHEMBL3366820 | 0.82 | KDR (0.44) | BRAFKIF11KDR | |
| SCHEMBL6385500 | 0.78 | RAF1 (0.58) | RAF1BRAFKIF11KDR | |
| SCHEMBL6384112 | 0.76 | RET (0.59) | RAF1BRAFKDR | |
| SCHEMBL6385523 | 0.75 | KDR (0.42) | RAF1KIF11KDR | |
| SCHEMBL6473984 | 0.75 | RAF1 (0.61) | RAF1BRAFKDR | |
| SCHEMBL6382098 | 0.75 | RAF1 (0.51) | RAF1BRAFKDR | |
| SCHEMBL6383754 | 0.74 | RAF1 (0.56) | RAF1BRAFKDR | |
| SCHEMBL6384240 | 0.73 | RAF1 (0.60) | RAF1BRAFKDR | |
| SCHEMBL6446742 | 0.73 | RIPK2 (0.51) | RAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8076488-B2 | Antiproliferative agents; angiogenesis inhibitors; anticancer agents | BAYER HEALTHCARE LLC (US) | 2011-12-13 | — | — | US | disclosed |
| US-8076488-B2 | Antiproliferative agents; angiogenesis inhibitors; anticancer agents | BAYER HEALTHCARE LLC (US) | 2011-12-13 | — | — | US | disclosed |