Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MOK | Q9UQ07 | 7/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138505 | 0.85 | MOK (0.46) | MOKLRRK2KMT2ANPC1RAB9A | |
| SCHEMBL4134697 | 0.82 | HIF1A (0.54) | LRRK2KMT2ANPC1RAB9AHIF1A | |
| SCHEMBL4147650 | 0.80 | SMN1; SMN2 (0.57) | MOKLRRK2KMT2ANPC1RAB9A | |
| SCHEMBL4139081 | 0.80 | HDAC1 (0.50) | MOKKMT2ANPC1RAB9AHIF1A | |
| SCHEMBL4137644 | 0.78 | HIF1A (0.52) | KMT2ANPC1RAB9AHIF1AEPAS1 | |
| SCHEMBL4138866 | 0.77 | HDAC1 (0.50) | MOKLRRK2KMT2ANPC1RAB9A | |
| SCHEMBL27963311 | 0.77 | KDM4E (0.50) | RAB9AKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL4137815 | 0.77 | AXL (0.47) | LMNAKDRHDAC1 | |
| SCHEMBL4139048 | 0.76 | MOK (0.47) | MOKLRRK2 | |
| SCHEMBL4147051 | 0.76 | HIF1A (0.51) | LRRK2KMT2ANPC1RAB9AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2527330-A1 | Inhibitors of the hedgehog pathway | Exelixis, Inc. (US) | 2012-11-28 | — | — | EP | disclosed |