Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 16/20 | 0.74 |
| ▸ | EPAS1 | Q99814 | 16/20 | 0.74 |
| ▸ | EP300 | Q09472 | 3/20 | 0.51 |
| ▸ | TLR3 | O15455 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063594 | 0.90 | HIF1A (0.58) | HIF1AEPAS1EP300 | |
| SCHEMBL14071611 | 0.87 | HIF1A (0.56) | HIF1AEPAS1EP300 | |
| SCHEMBL16509890 | 0.84 | HIF1A (0.75) | HIF1AEPAS1EP300 | |
| SCHEMBL14571754 | 0.83 | HIF1A (0.66) | HIF1AEPAS1EP300TLR3 | |
| SCHEMBL14063560 | 0.82 | HIF1A (0.65) | HIF1AEPAS1EP300 | |
| SCHEMBL15070035 | 0.82 | HIF1A (1.00) | HIF1AEPAS1EP300TLR3 | |
| SCHEMBL14063553 | 0.79 | HIF1A (0.74) | HIF1AEPAS1EP300 | |
| SCHEMBL14063595 | 0.78 | HIF1A (0.75) | HIF1AEPAS1EP300 | |
| SCHEMBL14071516 | 0.77 | HIF1A (0.75) | HIF1AEPAS1EP300 | |
| SCHEMBL14063593 | 0.77 | HIF1A (0.63) | HIF1AEPAS1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071795-B2 | Hypoxia inducible factor (Hif); for modulating mRNA translation within cells; prevents excessive vascularization | EMORY UNIVERSITY (US) | 2011-12-06 | — | — | US | disclosed |