Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.43 |
| ▸ | JUN | P05412 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19096959 | 0.87 | MAPK10 (0.55) | EGFRFGFR2STAT6JAK2BRD4 | |
| SCHEMBL16514597 | 0.84 | TTK (0.56) | EGFRFGFR2JAK2BRD4PTK2 | |
| SCHEMBL16513769 | 0.84 | EGFR (0.57) | EGFRFGFR2JAK2BRD4PTK2 | |
| SCHEMBL16514973 | 0.83 | EGFR (0.52) | EGFRFGFR2JAK2BRD4PTK2 | |
| SCHEMBL16513467 | 0.83 | EGFR (0.58) | EGFRFGFR2JAK2BRD4PTK2 | |
| SCHEMBL16514598 | 0.82 | EGFR (0.74) | EGFRFGFR2JAK2BRD4PTK2 | |
| SCHEMBL16514755 | 0.82 | EGFR (0.47) | EGFRFGFR2JAK2BRD4PTK2 | |
| SCHEMBL16514411 | 0.82 | MAPK10 (0.47) | EGFRFGFR2JAK2BRD4MAPK10 | |
| SCHEMBL29848075 | 0.82 | EGFR (0.74) | EGFRFGFR2JAK2BRD4PTK2 | |
| Fumaric Acid SCHEMBL16514713 | 0.81 | FGFR2 (0.66) | EGFRFGFR2JAK2BRD4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035936-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NeuPharma, Inc. (US) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015027222-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. (US) | 2015-02-26 | — | — | WO | disclosed |