Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | RPA1 | P27694 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16517421 | 0.88 | ELANE (0.46) | ELANEKDM4EGAAALDH1A1HPGD | |
| SCHEMBL16517321 | 0.86 | ELANE (0.39) | RPA1ELANEMAP2K1MEN1KMT2A | |
| SCHEMBL16516797 | 0.85 | PDE4A (0.44) | PDE4AKCNH2RPA1MEN1KMT2A | |
| SCHEMBL16516862 | 0.84 | PDE4A (0.51) | PDE4AKCNH2RPA1MEN1KMT2A | |
| SCHEMBL16517391 | 0.83 | ELANE (0.47) | RPA1ELANEMEN1KMT2AMAPT | |
| SCHEMBL16516955 | 0.83 | ELANE (0.41) | PDE4AKCNH2RPA1ELANEMEN1 | |
| SCHEMBL16516406 | 0.83 | ELANE (0.41) | RPA1ELANEMEN1KMT2AMAPT | |
| SCHEMBL16517324 | 0.83 | MAPK8 (0.41) | PDE4AKCNH2MAP2K1MEN1KMT2A | |
| SCHEMBL16517270 | 0.80 | MRGPRX4 (0.39) | MEN1KMT2AKDM4EMAPTGAA | |
| SCHEMBL16516510 | 0.80 | ELANE (0.38) | RPA1ELANEMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504206-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | H. Hoffnabb-La Roche Ag (CH) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018037059-A1 | 2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-03-01 | — | — | WO | disclosed |
| EP-3036230-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015025025-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |