Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 10/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16517726 | 0.94 | MAP3K14 (0.34) | ROCK2MAP3K14 | |
| SCHEMBL16516873 | 0.85 | MAP3K14 (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGROCK2 | |
| SCHEMBL16516868 | 0.85 | MAP3K14 (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGROCK2 | |
| SCHEMBL16517273 | 0.81 | MAP3K14 (0.38) | IRAK4MAP3K14 | |
| SCHEMBL16516775 | 0.81 | MAP3K14 (0.35) | MAP3K14 | |
| SCHEMBL16517576 | 0.80 | MAP3K14 (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGMAP3K14 | |
| SCHEMBL16505904 | 0.79 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL16505432 | 0.79 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL16505433 | 0.79 | MAP3K14 (0.56) | MAP3K14 | |
| SCHEMBL16517629 | 0.76 | MAP3K14 (0.42) | ROCK2MAP3K14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3036229-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| WO-2015025026-A1 | ALKYNYL ALCOHOLS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-26 | — | — | WO | disclosed |