SCHEMBL1652508

SCHEMBL1652508

Cc1ccc(Cc2nn(CO)c(=O)n2C)c(F)c1Oc1cc(C#N)cc(C(F)F)c1

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.54
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
EPAS1 Q99814 2/20 0.33
RORC P51449 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1653338 0.91 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL1654871 0.91 CYP3A4 (0.44) CYP3A4CYP2C9CYP2C19EPAS1KCNH2
SCHEMBL11904806 0.91 CYP3A4 (0.58) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL11904805 0.88 CYP3A4 (0.56) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL1653573 0.88 CYP3A4 (0.49) CYP3A4CYP2C9CYP2C19EPAS1
SCHEMBL5179004 0.83 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL4801622 0.83 CYP3A4 (0.77) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL11904782 0.83 CYP3A4 (0.48) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL11904215 0.83 CYP3A4 (0.52) CYP3A4CYP2C9CYP2C19EPAS1RORC
SCHEMBL5178759 0.82 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19EPAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773790-B1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2012-08-15 EP claimed
JP-4675959-B2 2011-04-27 JP claimed
EP-1773790-A1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-04-18 EP claimed
WO-2006010545-A1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-02-02 WO claimed
EP-1773790-B1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS HOFFMANN LA ROCHE (CH) 2012-08-15 EP disclosed
EP-1773790-A1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F.HOFFMANN-LA ROCHE AG (CH) 2007-04-18 EP disclosed
WO-2006010545-A1 BENZYLTRIAZOLONE COMPOUNDS AS NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-02-02 WO disclosed