Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.75 |
| ▸ | PIM1 | P11309 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16525061 | 0.87 | LRRK2 (0.72) | LRRK2 | |
| SCHEMBL16525278 | 0.86 | LRRK2 (0.75) | LRRK2PIM1 | |
| SCHEMBL16022150 | 0.85 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16525366 | 0.85 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL16525360 | 0.85 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL16022949 | 0.84 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16525284 | 0.84 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL31540072 | 0.83 | LRRK2 (0.72) | LRRK2 | |
| SCHEMBL16525460 | 0.83 | LRRK2 (0.74) | LRRK2 | |
| SCHEMBL16525280 | 0.83 | LRRK2 (0.74) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3035800-B1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME (US) | 2019-10-09 | — | — | EP | disclosed |
| US-9718818-B2 | Compounds inhibiting leucine-rich repeat kinase enzyme activity | MERCK SHARP & DOHME CORP. (US) | 2017-08-01 | — | — | US | disclosed |
| US-20160200722-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2016-07-14 | — | — | US | disclosed |
| WO-2015026683-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2015-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200722-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | LRRK2, LRRC47, LMTK2 | LRRK2 1/4885PIM1 1446/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.