Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.38 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034020 | 0.95 | PDE4B (0.68) | PDE4BTP53SIRT2SIRT1SIRT3 | |
| SCHEMBL3029591 | 0.93 | PDE4B (0.67) | PDE4BTP53RIPK1HTR1AADRA1D | |
| SCHEMBL3033083 | 0.88 | PDE4B (0.76) | PDE4BTP53HTR1AADRA1DADRA1A | |
| SCHEMBL3029143 | 0.85 | PDE4B (0.67) | PDE4BTP53HTR1AADRA1DADRA1A | |
| SCHEMBL4706065 | 0.84 | PDE4B (0.70) | PDE4BTP53SMN1; SMN2 | |
| SCHEMBL4705598 | 0.84 | PDE4B (0.72) | PDE4BTP53HTR1AADRA1DADRA1A | |
| SCHEMBL3022893 | 0.83 | PDE4B (0.55) | PDE4B | |
| SCHEMBL4708446 | 0.83 | PDE4B (0.84) | PDE4BTP53HTR1AADRA1DADRA1A | |
| SCHEMBL4058811 | 0.82 | PDE4B (0.70) | PDE4BHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL4708948 | 0.81 | PDE4B (0.58) | PDE4BTP53PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4679154-B2 | — | — | 2011-04-27 | — | — | JP | claimed |
| JP-2006515302-A | — | — | 2006-05-25 | — | — | JP | claimed |
| EP-1575926-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | Almirall Prodesfarma, S.A. (ES) | 2005-09-21 | — | — | EP | claimed |
| WO-2004058729-A1 | NEW PYRIDAZIN-3(2H)-ONE DERIVATIVES | ALMIRALL PRODESFARMA SA (ES) | 2004-07-15 | — | — | WO | claimed |