Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 18/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 11/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1427062 | 1.00 | GCK (0.62) | GCKKCNH2HRH3LIPE | |
| SCHEMBL1427090 | 0.91 | GCK (0.64) | GCKKCNH2HRH3 | |
| SCHEMBL1652741 | 0.91 | GCK (0.64) | GCKKCNH2HRH3 | |
| SCHEMBL1427136 | 0.91 | GCK (0.74) | GCKKCNH2 | |
| SCHEMBL1427058 | 0.90 | GCK (0.58) | GCKKCNH2HRH3LIPE | |
| SCHEMBL1426951 | 0.86 | GCK (0.59) | GCKKCNH2HRH3 | |
| SCHEMBL1427115 | 0.86 | GCK (0.54) | GCKKCNH2HRH3LIPE | |
| SCHEMBL1426864 | 0.85 | GCK (0.85) | GCKKCNH2 | |
| SCHEMBL1377326 | 0.85 | GCK (0.71) | GCKKCNH2 | |
| SCHEMBL2655987 | 0.83 | GCK (0.53) | GCKKCNH2HRH3LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305674-A1 | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |