Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 10/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16530421 | 1.00 | JAK2 (0.52) | JAK2PTK2JAK3 | |
| SCHEMBL521424 | 0.90 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL521013 | 0.90 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL521014 | 0.90 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL521713 | 0.86 | JAK2 (0.55) | JAK2PTK2JAK3 | |
| SCHEMBL519670 | 0.81 | JAK2 (0.65) | JAK2PTK2JAK3 | |
| SCHEMBL521354 | 0.80 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL521985 | 0.80 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL521353 | 0.80 | JAK2 (0.53) | JAK2PTK2JAK3 | |
| SCHEMBL16530353 | 0.76 | JAK2 (0.58) | JAK2PTK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-B1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON INC (US) | 2015-03-04 | — | — | EP | claimed |