Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 13/20 | 0.62 |
| ▸ | KIT | P10721 | 9/20 | 0.62 |
| ▸ | KDR | P35968 | 4/20 | 0.62 |
| ▸ | ABL1 | P00519 | 12/20 | 0.61 |
| ▸ | BCR | P11274 | 6/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.59 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | LDLR | P01130 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 1/20 | 0.59 |
| ▸ | CA3 | P07451 | 1/20 | 0.59 |
| ▸ | YES1 | P07947 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1929253 | 0.92 | PDGFRA (0.67) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1928111 | 0.90 | PDGFRA (0.60) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1654414 | 0.88 | PDGFRA (0.65) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1928330 | 0.86 | PDGFRA (0.68) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1655072 | 0.86 | ABL1 (0.81) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL27549082 | 0.84 | ABL1 (0.66) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1408815 | 0.83 | ABL1 (0.77) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1928115 | 0.83 | PDGFRA (0.66) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL1927086 | 0.83 | ABL1 (0.66) | PDGFRAKITKDRABL1BCR | |
| SCHEMBL27606811 | 0.83 | PDGFRA (0.66) | PDGFRAKITKDRABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070129389-A1 | Use of pyridinyl-pyrimidinylamino-benzamide derivatives for the treatment of amyloid related disorders | NOVARTIS AG (CH) | 2007-06-07 | — | — | US | claimed |
| EP-2606890-A1 | Combinations comprising BCR-ABL/C-KIT/PDGF-R TK inhibitors for treating cancer | Novartis AG (CH) | 2013-06-26 | — | — | EP | disclosed |
| US-20120252811-A1 | COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER | BURKE GREGORY PETER (US) | 2012-10-04 | — | — | US | disclosed |
| EP-2368889-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2011-09-28 | — | — | EP | disclosed |
| US-20110218187-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2011-09-08 | — | — | US | disclosed |
| EP-2357182-A1 | Inhibitors of tyrosine kinases | Novartis AG (CH) | 2011-08-17 | — | — | EP | disclosed |
| US-7956053-B2 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2011-06-07 | — | — | US | disclosed |
| EP-2314297-A1 | Combinations comprising bcr-abl/c-kit/pdgf-r tk inhibitors for treating cancer | Novartis AG (CH) | 2011-04-27 | — | — | EP | disclosed |
| US-7687512-B2 | 4-Methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide; for neurodegenerative diseases like Alzheimer's disease, Down's Syndrome, memory and cognitive impairment, dementia, amyloid neuropathies, brain inflammation, nerve and brain trauma | NOVARTIS AG (CH) | 2010-03-30 | — | — | US | disclosed |
| US-20090286821-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2009-11-19 | — | — | US | disclosed |
| US-7569566-B2 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | NOVARTIS AG (CH) | 2009-08-04 | — | — | US | disclosed |
| EP-1532138-B1 | INHIBITORS OF TYROSINE KINASES | NOVARTIS AG (CH) | 2008-11-19 | — | — | EP | disclosed |
| US-20080188451-A1 | INHIBITORS OF TYROSINE KINASES | BREITENSTEIN WERNER | 2008-08-07 | — | — | US | disclosed |
| CN-101045727-A | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2007-10-03 | — | — | CN | disclosed |
| CN-1324022-C | Tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2007-07-04 | — | — | CN | disclosed |
| US-20070129389-A1 | Use of pyridinyl-pyrimidinylamino-benzamide derivatives for the treatment of amyloid related disorders | NOVARTIS AG (CH) | 2007-06-07 | — | — | US | disclosed |
| US-20070093506-A1 | Inhibitors of tyrosine kinases | BREITENSTEIN WERNER | 2007-04-26 | — | — | US | disclosed |
| US-7169791-B2 | Inhibitors of tyrosine kinases | NOVARTIS AG (CH) | 2007-01-30 | — | — | US | disclosed |
| US-20060167015-A1 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | NOVARTIS AG (CH) | 2006-07-27 | — | — | US | disclosed |
| CN-1675195-A | Tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2005-09-28 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070093506-A1 | Inhibitors of tyrosine kinases | ABL1, BTK, FLT3 | PDGFRA 382/4885KIT 254/4885KDR 312/4885 |
| US-20110218187-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | PDGFRA 382/4885KIT 254/4885KDR 312/4885 |
| US-20120252811-A1 | COMBINATIONS OF THERAPEUTIC AGENTS FOR TREATING CANCER | KIT, ABL1, PDGFRB | PDGFRA 4/4885KIT 1/4885KDR 19/4885 |
| US-20070129389-A1 | Use of pyridinyl-pyrimidinylamino-benzamide derivatives for the treatment of amyloid related disorders | TIE1, ABL2, FYN | PDGFRA 5/4885KIT 22/4885KDR 7/4885 |
| US-20080188451-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | PDGFRA 382/4885KIT 254/4885KDR 312/4885 |
| US-20090286821-A1 | INHIBITORS OF TYROSINE KINASES | ABL1, BTK, FLT3 | PDGFRA 382/4885KIT 254/4885KDR 312/4885 |
| US-20060167015-A1 | 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazol1yl)-3-(trifluoromethyl)phenyl]benzamide or an N-oxide or salts; anticarcinogenic agent (leukaemia) | ABL1, CDK2, CDKN1A | PDGFRA 440/4885KIT 667/4885KDR 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.