Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.80 |
| ▸ | IGF1R | P08069 | 14/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12184941 | 0.90 | ALK (0.82) | ALKIGF1R | |
| SCHEMBL15022214 | 0.90 | ALK (0.82) | ALKIGF1R | |
| SCHEMBL15022358 | 0.89 | ALK (1.00) | ALKIGF1R | |
| SCHEMBL12184939 | 0.89 | ALK (1.00) | ALKIGF1R | |
| SCHEMBL15022238 | 0.89 | ALK (0.89) | ALKIGF1R | |
| SCHEMBL15023219 | 0.89 | ALK (1.00) | ALKIGF1R | |
| SCHEMBL12185031 | 0.89 | ALK (0.89) | ALKIGF1R | |
| SCHEMBL15023221 | 0.89 | ALK (1.00) | ALKIGF1R | |
| SCHEMBL15022479 | 0.89 | ALK (1.00) | ALKIGF1R | |
| SCHEMBL12185006 | 0.89 | ALK (1.00) | ALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2600874-B1 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE | AMGEN INC (US) | 2015-03-04 | — | — | EP | disclosed |