Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 14/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23587994 | 1.00 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| SCHEMBL23588001 | 1.00 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| SCHEMBL28818402 | 1.00 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| Hydrochloric Acid SCHEMBL28818392 | 0.99 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| Hydrochloric Acid SCHEMBL30175190 | 0.99 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| Hydrochloric Acid SCHEMBL17939793 | 0.99 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| Hydrochloric Acid SCHEMBL28818391 | 0.99 | CASR (0.52) | CASRMEN1LMNAPOLBHTT | |
| SCHEMBL17939892 | 0.91 | CASR (0.59) | CASRMEN1LMNAPOLBHTT | |
| SCHEMBL17939923 | 0.91 | CASR (0.59) | CASRMEN1LMNAPOLBHTT | |
| SCHEMBL16548161 | 0.91 | CASR (0.59) | CASRMEN1LMNAPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230049917-A1 | Pharmaceutical Composition of CASR Modulators and Methods and Uses Thereof | LUPIN LIMITED (IN) | 2023-02-16 | — | — | US | disclosed |
| WO-2021130779-A1 | PHARMACEUTICAL COMPOSITION OF CASR MODULATORS AND METHODS AND USES THEREOF | LUPIN LIMITED (IN) | 2021-07-01 | — | — | WO | disclosed |
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| US-20160214924-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-07-28 | — | — | US | disclosed |
| WO-2015028938-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230049917-A1 | Pharmaceutical Composition of CASR Modulators and Methods and Uses Thereof | CASR, CALCR, PTH1R | CASR 1/4885MEN1 744/4885LMNA 3021/4885 |
| US-20160214924-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | CASR, RYR2, RYR1 | CASR 1/4885MEN1 2646/4885LMNA 1996/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.