Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 16/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 14/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.44 |
| ▸ | PRKACA | P17612 | 4/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.44 |
| ▸ | AKT1 | P31749 | 3/20 | 0.44 |
| ▸ | PRKCG | P05129 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | GSK3A | P49840 | 3/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.44 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.44 |
| ▸ | PRKX | P51817 | 3/20 | 0.44 |
| ▸ | NEK4 | P51957 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.44 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.44 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17939950 | 1.00 | ROCK1 (0.46) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL16548216 | 0.93 | ROCK1 (0.42) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL16540266 | 0.93 | ROCK1 (0.42) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL16548152 | 0.90 | ROCK1 (0.45) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL17939937 | 0.90 | ROCK1 (0.45) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL16548154 | 0.90 | ROCK1 (0.48) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL16548224 | 0.90 | ROCK1 (0.46) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL17939940 | 0.90 | ROCK1 (0.46) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| Hydrochloric Acid SCHEMBL16540150 | 0.89 | ROCK1 (0.47) | ROCK1ROCK2PRKG1PRKACARPS6KB1 | |
| SCHEMBL17939796 | 0.89 | ROCK1 (0.42) | ROCK1ROCK2PRKG1PRKACARPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| US-9493396-B2 | Substituted naphthalene compounds as calcium sensing receptor modulators | LUPIN ATLANTIS HOLDINGS SA (CH) | 2016-11-15 | — | — | US | disclosed |
| WO-2015028938-A1 | SUBSTITUTED NAPHTHALENE COMPOUNDS AS CALCIUM SENSING RECEPTOR MODULATORS | LUPIN LIMITED (IN) | 2015-03-05 | — | — | WO | disclosed |