Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 15/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445762 | 0.82 | KDR (0.68) | ABCB1KDRTRPV4 | |
| SCHEMBL429577 | 0.80 | ABCB1 (0.61) | ABCB1KDR | |
| SCHEMBL1654453 | 0.77 | KDR (0.49) | ABCB1KDR | |
| SCHEMBL427599 | 0.74 | ABCB1 (0.79) | ABCB1KDRKDM4EMAPT | |
| SCHEMBL427658 | 0.74 | ABCB1 (0.69) | ABCB1KDR | |
| SCHEMBL446249 | 0.74 | KDR (0.70) | ABCB1KDRMAPT | |
| SCHEMBL3106416 | 0.73 | KDR (0.66) | ABCB1KDR | |
| SCHEMBL426633 | 0.72 | ABCB1 (1.00) | ABCB1KDRKDM4EMAPT | |
| SCHEMBL3108804 | 0.72 | KDR (0.65) | ABCB1KDR | |
| SCHEMBL427754 | 0.72 | KDR (0.55) | ABCB1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2311829-A1 | Substituted alkylamine derivatives and methods of use | Amgen Inc. (US) | 2011-04-20 | — | — | EP | disclosed |