Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.54 |
| ▸ | AURKA | O14965 | 3/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.49 |
| ▸ | STAT6 | P42226 | 6/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | BRD4 | O60885 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1654501 | 0.92 | RPS6KA3 (0.57) | RPS6KA3AURKACDK4STAT6JAK2 | |
| SCHEMBL1654507 | 0.91 | RPS6KA3 (0.56) | RPS6KA3AURKACDK4STAT6PTK2 | |
| SCHEMBL4284037 | 0.89 | STAT6 (0.54) | RPS6KA3AURKASTAT6PTK2JAK2 | |
| SCHEMBL27824864 | 0.88 | RPS6KA3 (0.62) | RPS6KA3AURKACDK4STAT6PTK2 | |
| SCHEMBL1657539 | 0.88 | AURKA (0.48) | RPS6KA3AURKACDK4PTK2JAK2 | |
| SCHEMBL1657536 | 0.88 | AURKA (0.48) | RPS6KA3AURKACDK4PTK2JAK2 | |
| SCHEMBL1656272 | 0.88 | RPS6KA3 (0.54) | RPS6KA3AURKACDK4STAT6JAK2 | |
| SCHEMBL4283758 | 0.87 | STAT6 (0.58) | RPS6KA3AURKACDK4STAT6JAK2 | |
| SCHEMBL1657475 | 0.86 | RPS6KA3 (0.55) | RPS6KA3AURKACDK4STAT6PTK2 | |
| SCHEMBL1654492 | 0.86 | RPS6KA3 (0.50) | RPS6KA3AURKACDK4STAT6PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | claimed |
| JP-2011511034-A | — | — | 2011-04-07 | — | — | JP | claimed |
| EP-2247591-A1 | PYRROLO [2, 3-D]PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-11-10 | — | — | EP | claimed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | claimed |
| WO-2009098236-A1 | PYRROLO [2, 3-D] PYRIDINES AND USE THEREOF AS TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-08-13 | — | — | WO | claimed |
| US-8420657-B2 | Pyrrolo[2,3-D]pyrimidines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2013-04-16 | — | — | US | disclosed |
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | NOVARTIS AG | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203688-A1 | HETEROCYCLIC COMPOUNDS | ABL1, JAK2, JAK1 | RPS6KA3 303/4885AURKA 755/4885CDK4 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.