Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.34 |
| ▸ | CALCRL | Q16602 | 3/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1655061 | 1.00 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL13818335 | 1.00 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3799236 | 1.00 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL1655063 | 1.00 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3799238 | 1.00 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3799240 | 1.00 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3975388 | 0.96 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3965585 | 0.96 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3975386 | 0.96 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 | |
| SCHEMBL3965581 | 0.96 | ADRB3 (0.46) | ADRB3ADRA2BADRA2CCYP3A4RAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305698-A2 | Macrocyclic inhibitors of Hepatitis C virus replication | Intermune, Inc. (US) | 2011-04-06 | — | — | EP | disclosed |