Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23906959 | 0.91 | MAOB (0.79) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL22964320 | 0.85 | MAOB (0.53) | MAOBMEN1KMT2AALOX5LMNA | |
| SCHEMBL5791635 | 0.84 | MAOB (0.69) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL31644032 | 0.84 | MAOB (0.69) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL21477256 | 0.83 | MAOB (0.67) | MAOBAPP | |
| SCHEMBL4852115 | 0.83 | MAOB (0.67) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL13703986 | 0.83 | MAOB (0.67) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL16551263 | 0.83 | MAOB (0.67) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL7743406 | 0.83 | MAOB (0.67) | MAOBMEN1KMT2AABCB1APP | |
| SCHEMBL21582181 | 0.81 | MAOB (0.65) | MAOBMEN1KMT2AABCB1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2516445-B1 | TRICYCLIC DERIVATIVES AND THEIR PHARMACEUTICAL USE AND COMPOSITIONS | CEPHALON INC (US) | 2015-03-11 | — | — | EP | disclosed |