Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 5/20 | 0.77 |
| ▸ | CA12 | O43570 | 5/20 | 0.61 |
| ▸ | CA1 | P00915 | 5/20 | 0.61 |
| ▸ | CA2 | P00918 | 5/20 | 0.61 |
| ▸ | CA4 | P22748 | 5/20 | 0.61 |
| ▸ | CA5A | P35218 | 5/20 | 0.61 |
| ▸ | CA7 | P43166 | 5/20 | 0.61 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.61 |
| ▸ | MAOB | P27338 | 2/20 | 0.61 |
| ▸ | NT5E | P21589 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880659 | 0.88 | S1PR1 (0.65) | S1PR1MAOBMAPTTP53MAOA | |
| SCHEMBL1654596 | 0.87 | S1PR1 (1.00) | S1PR1CA12CA1CA2CA4 | |
| SCHEMBL1654616 | 0.87 | S1PR1 (1.00) | S1PR1CA12CA1CA2CA4 | |
| SCHEMBL3885669 | 0.87 | S1PR1 (0.64) | S1PR1CA12CA1CA2CA4 | |
| SCHEMBL3879045 | 0.87 | S1PR1 (0.64) | S1PR1CA12CA1CA2CA4 | |
| SCHEMBL14322649 | 0.87 | S1PR1 (0.82) | S1PR1CA12CA1CA2CA4 | |
| SCHEMBL1654629 | 0.87 | S1PR1 (0.66) | S1PR1MAOBMAPTTP53MAOA | |
| SCHEMBL14322300 | 0.85 | S1PR1 (0.68) | S1PR1MAOBMAPTTP53MAOA | |
| SCHEMBL3883039 | 0.85 | S1PR1 (0.64) | S1PR1MAOBMAPTTP53MAOA | |
| SCHEMBL3880669 | 0.85 | S1PR1 (0.64) | S1PR1MAOBMAPTTP53MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9572792-B2 | Coumarin compounds as receptor modulators with therapeutic utility | ALLERGAN, INC. (US) | 2017-02-21 | — | — | US | claimed |
| US-20150265573-A1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. | 2015-09-24 | — | — | US | claimed |
| US-9073888-B2 | Coumarin compounds as receptor modulators with therapeutic utility | ALLERGAN, INC. (US) | 2015-07-07 | — | — | US | claimed |
| EP-2491023-B1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN INC (US) | 2014-12-31 | — | — | EP | claimed |
| US-20120328661-A1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. (US) | 2012-12-27 | — | — | US | claimed |
| EP-2491023-A2 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | Allergan, Inc. (US) | 2012-08-29 | — | — | EP | claimed |
| WO-2011050054-A2 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. (US) | 2011-04-28 | — | — | WO | claimed |
| US-9572792-B2 | Coumarin compounds as receptor modulators with therapeutic utility | ALLERGAN, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-20150265573-A1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. | 2015-09-24 | — | — | US | disclosed |
| US-9073888-B2 | Coumarin compounds as receptor modulators with therapeutic utility | ALLERGAN, INC. (US) | 2015-07-07 | — | — | US | disclosed |
| EP-2491023-B1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN INC (US) | 2014-12-31 | — | — | EP | disclosed |
| US-20120328661-A1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. (US) | 2012-12-27 | — | — | US | disclosed |
| EP-2491023-A2 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | Allergan, Inc. (US) | 2012-08-29 | — | — | EP | disclosed |
| WO-2011050054-A2 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | ALLERGAN, INC. (US) | 2011-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150265573-A1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | S1PR3, S1PR1, S1PR2 | S1PR1 2/4885CA12 4409/4885CA1 4396/4885 |
| US-20120328661-A1 | COUMARIN COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY | S1PR3, S1PR1, S1PR2 | S1PR1 2/4885CA12 4409/4885CA1 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.