SCHEMBL1655455

SCHEMBL1655455

NCCn1nc2c(c1C(=O)O)CCc1cnccc1-2

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 5/20 0.36
PDPK1 O15530 1/20 0.36
AURKA O14965 4/20 0.32
CCNA2 P20248 4/20 0.32
CCNA1 P78396 4/20 0.32
KDM4C Q9H3R0 2/20 0.32
NPSR1 Q6W5P4 1/20 0.32
BRAF P15056 1/20 0.32
MAPK3 P27361 1/20 0.32
MAPK1 P28482 1/20 0.32
ROCK2 O75116 1/20 0.31
GRK2 P25098 1/20 0.31
MAPKAPK2 P49137 1/20 0.31
PLK1 P53350 1/20 0.31
HCAR2 Q8TDS4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4257712 0.99 CDK2 (0.36) CDK2PDPK1AURKACCNA2CCNA1
Hydrochloric Acid SCHEMBL1658167 0.92 CDK2 (0.42) CDK2PDPK1AURKACCNA2CCNA1
Hydrochloric Acid SCHEMBL1658063 0.91 CDK2 (0.40) CDK2PDPK1AURKACCNA2CCNA1
SCHEMBL6793189 0.89 CDK2 (0.35) CDK2PDPK1AURKACCNA2CCNA1
SCHEMBL6793304 0.88 KDM4C (0.37) CDK2AURKACCNA2CCNA1KDM4C
Trifluoroacetic Acid SCHEMBL4270462 0.88 CDK2 (0.41) CDK2PDPK1AURKACCNA2CCNA1
SCHEMBL1659385 0.87 CDK2 (0.34) CDK2PDPK1AURKACCNA2CCNA1
Hydrochloric Acid SCHEMBL6793245 0.84 CCNA2 (0.37) CDK2CCNA2CCNA1NPSR1BRAF
SCHEMBL6794493 0.84 CDK2 (0.36) CDK2PDPK1AURKACCNA2CCNA1
SCHEMBL6799797 0.84 AAK1 (0.35) CDK2PDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011041784-A1 METHODS FOR DIAGNOSING AND TREATING CANCER MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2011-04-07 WO disclosed