Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 18/20 | 0.86 |
| ▸ | KDR | P35968 | 10/20 | 0.86 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4995124 | 0.92 | AXL (1.00) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL4993438 | 0.92 | AXL (1.00) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL4993590 | 0.92 | AXL (1.00) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL11317396 | 0.92 | AXL (1.00) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL4992302 | 0.90 | AXL (0.80) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL4997549 | 0.90 | AXL (0.79) | AXLKDRINSR | |
| Formic Acid SCHEMBL4989624 | 0.89 | AXL (0.92) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL4241756 | 0.87 | AXL (0.80) | AXLKDRINSRAURKACDK4 | |
| SCHEMBL4989676 | 0.87 | AXL (0.75) | AXLKDRINSR | |
| SCHEMBL4238730 | 0.86 | AXL (0.73) | AXLKDRINSRAURKACDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160243085-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | MIDCAP FINANCIAL TRUST | 2016-08-25 | — | — | US | disclosed |
| US-9353126-B2 | Substituted triazoles useful as Axl inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20150072959-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | MIDCAP FINANCIAL TRUST | 2015-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150072959-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, MERTK | AXL 1/4885KDR 70/4885INSR 247/4885 |
| US-20160243085-A1 | SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS | AXL, TYRO3, MERTK | AXL 1/4885KDR 70/4885INSR 247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.