Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 19/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2644297 | 0.93 | GCK (0.71) | GCK | |
| Trifluoroacetic Acid SCHEMBL1656618 | 0.83 | GCK (0.75) | GCK | |
| SCHEMBL5071857 | 0.81 | GCK (0.78) | GCK | |
| Trifluoroacetic Acid SCHEMBL1656538 | 0.81 | GCK (0.74) | GCK | |
| SCHEMBL1657701 | 0.81 | GCK (0.82) | GCK | |
| SCHEMBL1656395 | 0.80 | GCK (0.79) | GCK | |
| SCHEMBL1656688 | 0.80 | GCK (0.81) | GCK | |
| SCHEMBL926399 | 0.80 | GCK (0.76) | GCK | |
| SCHEMBL1657053 | 0.79 | GCK (0.80) | GCK | |
| SCHEMBL1657309 | 0.79 | GCK (0.70) | GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932394-B2 | 1-{[5-[4-(Methylsulfonyl)phenoxy]-2-(2-pyridinyl)-1H-benzimidazol-6-yl]methyl}-5-thioxo-2-pyrrolidinone;glucokinase activator; antidiabetic agents; obesity; prevention of retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis; antiischemic agents; cardiotonic agents | MSD K.K. (JP) | 2011-04-26 | — | — | US | disclosed |