Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.57 |
| ▸ | BRD4 | O60885 | 7/20 | 0.57 |
| ▸ | PTK2 | Q05397 | 12/20 | 0.47 |
| ▸ | JAK3 | P52333 | 9/20 | 0.47 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.45 |
| ▸ | SRPK2 | P78362 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | PTK2B | Q14289 | 4/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | STK16 | O75716 | 1/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16580749 | 0.91 | JAK2 (0.58) | JAK2BRD4PTK2JAK3JAK1 | |
| SCHEMBL16570534 | 0.86 | SRPK1 (0.45) | JAK2BRD4PTK2JAK3SRPK1 | |
| SCHEMBL16580867 | 0.86 | SRPK1 (0.45) | JAK2BRD4PTK2JAK3SRPK1 | |
| SCHEMBL16570733 | 0.85 | SRPK2 (0.44) | JAK2BRD4PTK2JAK3SRPK1 | |
| SCHEMBL16580998 | 0.85 | SRPK2 (0.44) | JAK2BRD4PTK2JAK3SRPK1 | |
| SCHEMBL16570669 | 0.85 | SRPK2 (0.48) | JAK2BRD4PTK2JAK3SRPK1 | |
| SCHEMBL16570877 | 0.84 | PTK2 (0.47) | JAK2PTK2JAK3SRPK1SRPK2 | |
| SCHEMBL16570449 | 0.84 | PTK2 (0.47) | JAK2PTK2JAK3SRPK1SRPK2 | |
| SCHEMBL16570739 | 0.84 | JAK2 (0.55) | JAK2BRD4PTK2JAK3SRPK1 | |
| SCHEMBL17958787 | 0.84 | PTK2 (0.47) | JAK2PTK2JAK3SRPK1SRPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2016-08-04 | — | — | US | claimed |
| WO-2015038417-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | claimed |
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2016-08-04 | — | — | US | disclosed |
| WO-2015038417-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | ASANA BIOSCIENCES, LLC (US) | 2015-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222014-A1 | COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS | SRC, PTK2, FYN | JAK2 9/4885BRD4 427/4885PTK2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.