SCHEMBL16570868

SCHEMBL16570868

CN(c1ncccc1Cn1ccc2cnc(Nc3ccc4[nH]cc(C5=CCNCC5)c4c3)nc21)S(C)(=O)=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SRPK1 Q96SB4 3/20 0.45
▸ SRPK2 P78362 2/20 0.45
▸ PTK2 Q05397 18/20 0.42
▸ JAK2 O60674 7/20 0.42
▸ JAK3 P52333 7/20 0.42
▸ PTK2B Q14289 4/20 0.40
▸ PLK4 O00444 1/20 0.39
▸ AURKA O14965 1/20 0.39
▸ PDPK1 O15530 1/20 0.39
▸ DAPK3 O43293 1/20 0.39
▸ ROCK2 O75116 1/20 0.39
▸ STK16 O75716 1/20 0.39
▸ PRKD3 O94806 1/20 0.39
▸ MAP4K4 O95819 1/20 0.39
▸ PAK4 O96013 1/20 0.39
▸ CHEK2 O96017 1/20 0.39
▸ NTRK1 P04629 1/20 0.39
▸ PRKCG P05129 1/20 0.39
▸ INSR P06213 1/20 0.39
▸ LCK P06239 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL17958776 1.00 SRPK1 (0.45) SRPK1SRPK2PTK2JAK2JAK3
SCHEMBL16569911 0.88 SRPK2 (0.48) SRPK1SRPK2PTK2JAK2JAK3
SCHEMBL16571171 0.87 SRPK1 (0.48) SRPK1SRPK2PTK2JAK2JAK3
SCHEMBL5210760 0.84 PTK2 (0.50) SRPK1PTK2JAK2JAK3PTK2B
SCHEMBL5213023 0.82 PTK2 (0.63) SRPK1PTK2JAK2JAK3PTK2B
SCHEMBL16569903 0.80 SRPK1 (0.54) SRPK1SRPK2PTK2JAK2JAK3
SCHEMBL17974110 0.80 STAT6 (0.40) PTK2JAK2JAK3PRKD3CYP3A4
Hydrochloric Acid SCHEMBL16571388 0.80 STAT6 (0.40) PTK2JAK2JAK3PRKD3CYP3A4
SCHEMBL16570821 0.79 SRPK1 (0.55) SRPK1SRPK2PTK2JAK2JAK3
SCHEMBL16570420 0.79 PTK2 (0.53) SRPK1SRPK2PTK2JAK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015038417-A1 COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS ASANA BIOSCIENCES, LLC (US) 2015-03-19 — — WO claimed
US-20160222014-A1 COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS ASANA BIOSCIENCES, LLC (US) 2016-08-04 — — US disclosed
WO-2015038417-A1 COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS ASANA BIOSCIENCES, LLC (US) 2015-03-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160222014-A1 COMPOUNDS FOR REGULATING FAK AND/OR SRC PATHWAYS SRC, PTK2, FYN SRPK1 478/4885SRPK2 301/4885PTK2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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