Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.71 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.71 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.64 |
| ▸ | TNKS | O95271 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.63 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.63 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.63 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.63 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.63 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.63 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.63 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.63 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.63 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30437346 | 1.00 | PARP1 (0.71) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL16571505 | 0.94 | PARP1 (0.74) | PARP1PARP2TNKSADORA1CDK6 | |
| SCHEMBL16571947 | 0.94 | PARP1 (0.67) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL30437099 | 0.94 | PARP1 (0.67) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL16571788 | 0.94 | PARP1 (0.67) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL16571790 | 0.94 | PARP1 (0.67) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL30437599 | 0.91 | PARP1 (0.68) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL16571679 | 0.91 | PARP1 (0.68) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL16571770 | 0.89 | PARP1 (0.70) | PARP1PARP2HSP90AA1HSP90AB1TNKS | |
| SCHEMBL30436980 | 0.89 | PARP1 (0.70) | PARP1PARP2HSP90AA1HSP90AB1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030557-B1 | A NOVEL PHTALAZINONE DERIVATIVES AND MANUFACTURING PROCESS THEREOF | IDIENCE CO LTD (KR) | 2023-05-31 | — | — | EP | disclosed |
| US-RE49338-E1 | Phthalazinone derivatives and manufacturing process thereof | IDIENCE CO., LTD. (KR) | 2022-12-20 | — | — | US | disclosed |
| US-9844550-B2 | Phtalazinone derivatives and manufacturing process thereof | ILDONG PHARM CO., LTD (KR) | 2017-12-19 | — | — | US | disclosed |
| US-20170182045-A1 | Novel Phtalazinone Derivatives and Manufacturing Process Thereof | IL DONG HOLDINGS CO., LTD (KR) | 2017-06-29 | — | — | US | disclosed |
| US-9682973-B2 | Phtalazinone derivatives and manufacturing process thereof | ILDONG PHARM CO., LTD (KR) | 2017-06-20 | — | — | US | disclosed |
| US-20160222003-A1 | Novel Phtalazinone Derivatives and Manufacturing Process Thereof | IL DONG HOLDINGS CO., LTD (KR) | 2016-08-04 | — | — | US | disclosed |
| EP-3030557-A1 | A NOVEL PHTALAZINONE DERIVATIVES AND MANUFACTURING PROCESS THEREOF | Ildong Pharm Co., Ltd. (KR) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015037939-A1 | A NOVEL PHTALAZINONE DERIVATIVES AND MANUFACTURING PROCESS THEREOF | ILDONG PHARM CO., LTD. (KR) | 2015-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160222003-A1 | Novel Phtalazinone Derivatives and Manufacturing Process Thereof | PARP15, PARP10, PARP1 | PARP1 3/4885PARP2 12/4885HSP90AA1 3304/4885 |
| US-20170182045-A1 | Novel Phtalazinone Derivatives and Manufacturing Process Thereof | PARP15, PARP10, NUDT5 | PARP1 4/4885PARP2 12/4885HSP90AA1 3244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.