Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 15/20 | 0.75 |
| ▸ | ABL1 | P00519 | 6/20 | 0.50 |
| ▸ | HCK | P08631 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.48 |
| ▸ | PRKDC | P78527 | 3/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12120704 | 0.91 | SRC (0.75) | SRCABL1HCKPDGFRBPIK3CD | |
| SCHEMBL1320636 | 0.90 | SRC (0.70) | SRCABL1KDRBCRBRAF | |
| SCHEMBL14982739 | 0.87 | SRC (0.77) | SRCABL1HCKPIK3CDEGFR | |
| SCHEMBL12123684 | 0.86 | SRC (0.71) | SRCABL1HCKPIK3CDEGFR | |
| SCHEMBL7515173 | 0.86 | SRC (0.76) | SRCABL1HCKPIK3CDEGFR | |
| SCHEMBL7506714 | 0.85 | SRC (1.00) | SRCABL1HCK | |
| SCHEMBL12120464 | 0.83 | SRC (0.71) | SRCABL1HCKPIK3CDEGFR | |
| SCHEMBL12123455 | 0.82 | ABL1 (0.70) | SRCABL1HCKPIK3CDEGFR | |
| SCHEMBL12068730 | 0.82 | SRC (1.00) | SRCABL1HCKPIK3CDEGFR | |
| SCHEMBL7515000 | 0.81 | SRC (1.00) | SRCABL1HCKPIK3CDEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980899-B2 | Methods of inhibiting Ire1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-17 | — | — | US | disclosed |