Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 14/20 | 0.53 |
| ▸ | CBFB | Q13951 | 5/20 | 0.53 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2294207 | 0.91 | CBFB (0.53) | GCKCBFBRUNX1NPC1RAB9A | |
| SCHEMBL2293097 | 0.90 | GCK (0.42) | GCKCBFB | |
| SCHEMBL1656662 | 0.88 | GCK (0.67) | GCKCBFBRUNX1NPC1RAB9A | |
| SCHEMBL2644621 | 0.88 | GCK (0.57) | GCKCBFBRUNX1NPC1RAB9A | |
| SCHEMBL1656653 | 0.86 | GCK (0.60) | GCKCBFBRUNX1NPC1RAB9A | |
| SCHEMBL2644799 | 0.85 | GCK (0.54) | GCKCBFBRUNX1NPC1RAB9A | |
| SCHEMBL1657389 | 0.85 | GCK (0.57) | GCKCBFB | |
| SCHEMBL2645623 | 0.84 | GCK (0.54) | GCKCBFBRUNX1NPC1RAB9A | |
| SCHEMBL2644457 | 0.84 | GCK (0.54) | GCKCBFB | |
| SCHEMBL2646067 | 0.84 | GCK (0.53) | GCKCBFBRUNX1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1905769-B1 | HETEROCYCLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | MSD KK (JP) | 2017-03-29 | — | — | EP | disclosed |
| EP-1810969-B1 | ARYLOXY-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | MSD KK (JP) | 2013-08-07 | — | — | EP | disclosed |
| US-7994331-B2 | Heterocycle-substituted benzimidazole derivative | MSD K.K. (JP) | 2011-08-09 | — | — | US | disclosed |
| US-7932394-B2 | 1-{[5-[4-(Methylsulfonyl)phenoxy]-2-(2-pyridinyl)-1H-benzimidazol-6-yl]methyl}-5-thioxo-2-pyrrolidinone;glucokinase activator; antidiabetic agents; obesity; prevention of retinopathy, nephropathy, neurosis, ischemic cardiopathy, arteriosclerosis; antiischemic agents; cardiotonic agents | MSD K.K. (JP) | 2011-04-26 | — | — | US | disclosed |
| US-20100087360-A1 | Heterocycle-substituted benzimidazole derivative | MSD K.K. (JP) | 2010-04-08 | — | — | US | disclosed |
| US-20080125429-A1 | Aryloxy-Substituted Benzimidazole Derivatives | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-05-29 | — | — | US | disclosed |
| EP-1905769-A1 | HETEROCYCLE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2008-04-02 | — | — | EP | disclosed |
| EP-1810969-A1 | ARYLOXY-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087360-A1 | Heterocycle-substituted benzimidazole derivative | GCK, GCKR, HK1 | GCK 1/4885CBFB 2061/4885RUNX1 1096/4885 |
| US-20080125429-A1 | Aryloxy-Substituted Benzimidazole Derivatives | GCK, GCKR, SLC5A1 | GCK 1/4885CBFB 1380/4885RUNX1 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.