Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.60 |
| ▸ | KLK7 | P49862 | 1/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | AHCY | P23526 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16574778 | 0.87 | DOT1L (0.53) | DOT1LPRKACAPLA2G2A | |
| SCHEMBL16578293 | 0.86 | DOT1L (0.68) | DOT1LPRKACAAHCY | |
| SCHEMBL23056319 | 0.84 | DOT1L (0.47) | DOT1LKLK7KLK5PRKACATDP1 | |
| SCHEMBL23056612 | 0.84 | DOT1L (0.47) | DOT1LKLK7KLK5PRKACATDP1 | |
| SCHEMBL16289550 | 0.83 | DOT1L (0.46) | DOT1LKLK7KLK5 | |
| SCHEMBL23157246 | 0.83 | DOT1L (0.46) | DOT1LKLK7KLK5 | |
| SCHEMBL16289546 | 0.83 | DOT1L (0.46) | DOT1LKLK7KLK5 | |
| SCHEMBL16289533 | 0.83 | DOT1L (0.46) | DOT1LKLK7KLK5 | |
| SCHEMBL15083579 | 0.83 | DOT1L (0.46) | DOT1LKLK7KLK5 | |
| SCHEMBL16289527 | 0.83 | DOT1L (0.46) | DOT1LKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150080549-A1 | PEPTIDE-COMPOUND CYCLIZATION METHOD | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2015-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150080549-A1 | PEPTIDE-COMPOUND CYCLIZATION METHOD | VIP, NGLY1, GLP1R | DOT1L 4554/4885KLK7 326/4885KLK5 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.