Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16583546 | 1.00 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL16583419 | 0.91 | PIK3CD (0.60) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL754924 | 0.91 | PIK3CD (0.60) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL16583249 | 0.89 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL16583247 | 0.89 | PIK3CD (0.47) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL16583379 | 0.85 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| SCHEMBL16583380 | 0.85 | PIK3CD (0.58) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL22529174 | 0.84 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL22529175 | 0.84 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA | |
| Hydrochloric Acid SCHEMBL29440950 | 0.84 | PIK3CD (0.57) | PIK3CDPIK3CGPIK3R1PIK3CBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3046563-B1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AS PI3-KINASE INHIBITORS | CALITOR SCIENCES LLC (US) | 2019-05-29 | — | — | EP | disclosed |
| US-9670194-B2 | Substituted aminopyrimidine compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2017-06-06 | — | — | US | disclosed |
| US-9518046-B2 | Substituted aminopyrimidine compounds and methods of use | CALITOR SCIENCES, LLC (US) | 2016-12-13 | — | — | US | disclosed |
| US-20160318913-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-11-03 | — | — | US | disclosed |
| CN-104513235-A | Substituted aminopyrimidine compound and use thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-04-15 | — | — | CN | disclosed |
| US-20150087663-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150087663-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, MYD88 | PIK3CD 2/4885PIK3CG 5/4885PIK3R1 10/4885 |
| US-20160318913-A1 | SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | PIK3CA, PIK3CD, MYD88 | PIK3CD 2/4885PIK3CG 6/4885PIK3R1 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.