SCHEMBL16587407

SCHEMBL16587407

Cc1cccc(F)c1Cn1ccc2ccc(CC(=O)O)cc21

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 19/20 0.57
HDAC8 Q9BY41 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11974969 0.92 SLC22A12 (0.54) SLC22A12HDAC8
SCHEMBL11977334 0.92 SLC22A12 (0.66) SLC22A12HDAC8
SCHEMBL11976836 0.86 SLC22A12 (0.66) SLC22A12HDAC8
SCHEMBL11974953 0.84 SLC22A12 (0.48) SLC22A12HDAC8
SCHEMBL11975788 0.81 SLC22A12 (0.43) SLC22A12HDAC8
SCHEMBL11976835 0.81 SLC22A12 (0.54) SLC22A12HDAC8
SCHEMBL11977339 0.81 SLC22A12 (0.46) SLC22A12HDAC8
SCHEMBL11974999 0.80 SLC22A12 (0.58) SLC22A12
SCHEMBL11976527 0.80 SLC22A12 (0.62) SLC22A12HDAC8
SCHEMBL11977062 0.79 HDAC8 (0.49) SLC22A12HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9359350-B2 Ring-fused compound SATO PHARMACEUTICAL CO., LTD. (JP) 2016-06-07 US disclosed
US-20150203490-A1 RING-FUSED COMPOUND SATO PHARMACEUTICAL CO., LTD. (JP) 2015-07-23 US disclosed
US-8987473-B2 Ring-fused compound SATO PHARMACEUTICAL CO., LTD. (JP) 2015-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150203490-A1 RING-FUSED COMPOUND URB2, RCOR1, RCC2 SLC22A12 394/4885HDAC8 2042/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.