Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14752132 | 0.83 | PIK3CD (0.34) | PIK3CD | |
| SCHEMBL14752172 | 0.83 | PIK3CD (0.34) | PIK3CD | |
| SCHEMBL12683378 | 0.82 | GRIN2B (0.36) | GRIN2BGRIN1MEN1ALDH1A1KMT2A | |
| SCHEMBL16472406 | 0.82 | GRIN2B (0.36) | GRIN2BGRIN1MEN1ALDH1A1KMT2A | |
| SCHEMBL16478751 | 0.78 | GRIN2B (0.35) | GRIN2BGRIN1 | |
| SCHEMBL16472312 | 0.77 | MEN1 (0.38) | GRIN2BGRIN1MEN1KMT2A | |
| SCHEMBL26151481 | 0.77 | KDM4E (0.33) | MEN1ALDH1A1KMT2A | |
| SCHEMBL25118501 | 0.77 | — | — | |
| SCHEMBL4573893 | 0.75 | PIK3CD (0.36) | GRIN2BPIK3CD | |
| SCHEMBL21195838 | 0.72 | PIK3CD (0.33) | LMNAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987268-B2 | Pyrrolopyridazine JAK3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-03-24 | — | — | US | disclosed |