Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 10/20 | 0.77 |
| ▸ | ITGA2 | P17301 | 7/20 | 0.77 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.77 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.60 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4260019 | 0.99 | ITGB1 (0.79) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL12084791 | 0.99 | ITGB1 (0.79) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL8239058 | 0.96 | ITGB1 (0.83) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL12084502 | 0.96 | ITGB1 (0.83) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL4255594 | 0.96 | ITGB1 (0.83) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL1487410 | 0.93 | ITGB1 (0.75) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL12084785 | 0.92 | ITGB1 (0.79) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL4253400 | 0.92 | ITGB1 (0.79) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL4253038 | 0.90 | ITGB1 (0.79) | ITGB1ITGA2ITGA4FKBP1AITGA5 | |
| SCHEMBL8245501 | 0.90 | ITGB1 (0.79) | ITGB1ITGA2ITGA4FKBP1AITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987306-B2 | Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-03-24 | — | — | US | disclosed |