Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL1 | P55085 | 7/20 | 0.77 |
| ▸ | GHSR | Q92847 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 2/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16598354 | 1.00 | F2RL1 (0.77) | F2RL1GHSRHPGDKDM4EABCG2 | |
| SCHEMBL16598622 | 0.93 | F2RL1 (0.72) | F2RL1GHSRHPGDABCG2SMO | |
| SCHEMBL16614971 | 0.92 | F2RL1 (0.81) | F2RL1GHSRHPGDKDM4EABCG2 | |
| SCHEMBL16615052 | 0.91 | F2RL1 (0.77) | F2RL1GHSRHPGDKDM4ESMO | |
| SCHEMBL16614931 | 0.91 | F2RL1 (0.79) | F2RL1GHSRHPGDKDM4EABCG2 | |
| SCHEMBL16614926 | 0.91 | F2RL1 (0.76) | F2RL1GHSRHPGDKDM4EABCG2 | |
| SCHEMBL16615045 | 0.91 | F2RL1 (0.79) | F2RL1GHSRHPGDKDM4EABCG2 | |
| SCHEMBL16615046 | 0.91 | F2RL1 (0.79) | F2RL1GHSRHPGDKDM4EABCG2 | |
| SCHEMBL16598400 | 0.91 | F2RL1 (0.72) | F2RL1GHSRHPGDKDM4ESMO | |
| SCHEMBL16614943 | 0.90 | F2RL1 (0.76) | F2RL1GHSRHPGDKDM4EABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3049418-A1 | IMIDAZOPYRIDAZINES USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | Vertex Pharmaceuticals Incorporated (US) | 2016-08-03 | — | — | EP | disclosed |
| WO-2015048245-A1 | IMIDAZOPYRIDAZINES USEFUL AS INHIBITORS OF THE PAR-2 SIGNALING PATHWAY | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-04-02 | — | — | WO | disclosed |