Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.65 |
| ▸ | RET | P07949 | 10/20 | 0.61 |
| ▸ | KDR | P35968 | 4/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 2/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.54 |
| ▸ | MUSK | O15146 | 1/20 | 0.54 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.54 |
| ▸ | PAK3 | O75914 | 1/20 | 0.54 |
| ▸ | STK10 | O94804 | 1/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | YES1 | P07947 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16599704 | 0.96 | RET (0.61) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL17443401 | 0.88 | RET (0.56) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL16599738 | 0.85 | FLT3 (0.71) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL17443450 | 0.84 | RET (0.56) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL16608675 | 0.82 | FLT3 (0.69) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL17443405 | 0.82 | RET (0.62) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL16608551 | 0.81 | RET (0.69) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL16608530 | 0.81 | FLT3 (0.70) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL18774662 | 0.81 | ALK (0.52) | FLT3RETKDRCSF1RPDGFRB | |
| SCHEMBL1254979 | 0.80 | RET (0.65) | FLT3RETKDRCSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015043492-A1 | SUBSTITUTED UREA DERIVATIVES AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-04-02 | — | — | WO | disclosed |
| WO-2015043492-A1 | SUBSTITUTED UREA DERIVATIVES AND USES THEREOF IN MEDICINE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2015-04-02 | — | — | WO | disclosed |