Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 19/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16600159 | 1.00 | GPR183 (0.67) | GPR183KCNH2ALDH1A1LMNATP53 | |
| SCHEMBL16599880 | 0.96 | GPR183 (0.70) | GPR183KCNH2 | |
| SCHEMBL16599882 | 0.96 | GPR183 (0.70) | GPR183KCNH2 | |
| SCHEMBL16599921 | 0.90 | GPR183 (0.74) | GPR183KCNH2 | |
| SCHEMBL16599924 | 0.90 | GPR183 (0.74) | GPR183KCNH2 | |
| SCHEMBL16600018 | 0.89 | GPR183 (0.77) | GPR183KCNH2 | |
| SCHEMBL16600017 | 0.89 | GPR183 (0.77) | GPR183KCNH2 | |
| SCHEMBL16600265 | 0.89 | GPR183 (0.76) | GPR183KCNH2 | |
| SCHEMBL16600267 | 0.89 | GPR183 (0.76) | GPR183KCNH2 | |
| SCHEMBL16600071 | 0.88 | GPR183 (0.78) | GPR183KCNH2ALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048567-A1 | SPIROCYCLIC EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |