Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 16/20 | 0.77 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.54 |
| ▸ | ATXN2 | Q99700 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CCR2 | P41597 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16600407 | 1.00 | GPR183 (0.77) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16599938 | 0.92 | GPR183 (0.73) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16599936 | 0.92 | GPR183 (0.73) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16599859 | 0.89 | GPR183 (0.66) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16599861 | 0.89 | GPR183 (0.66) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16599931 | 0.89 | GPR183 (0.73) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16599928 | 0.89 | GPR183 (0.73) | GPR183ENPP2ATXN2NPC1RAB9A | |
| SCHEMBL16598489 | 0.87 | GPR183 (1.00) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL16598486 | 0.87 | GPR183 (1.00) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL16599889 | 0.86 | GPR183 (0.77) | GPR183ENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015048567-A1 | SPIROCYCLIC EBI2 MODULATORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-04-02 | — | — | WO | disclosed |