Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 12/20 | 0.69 |
| ▸ | KDR | P35968 | 8/20 | 0.69 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.69 |
| ▸ | RET | P07949 | 4/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.69 |
| ▸ | ABL1 | P00519 | 3/20 | 0.69 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.69 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.69 |
| ▸ | BRAF | P15056 | 3/20 | 0.69 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.69 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.69 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.69 |
| ▸ | HTR1A | P08908 | 2/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.69 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.69 |
| ▸ | KIT | P10721 | 2/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.69 |
| ▸ | FLT1 | P17948 | 2/20 | 0.69 |
| ▸ | MAOA | P21397 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1660436 | 0.91 | RAF1 (0.67) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL16620832 | 0.90 | RAF1 (0.74) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL1660185 | 0.90 | RAF1 (0.67) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL1662323 | 0.89 | RAF1 (0.75) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL16621444 | 0.89 | RAF1 (0.68) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL1661876 | 0.88 | MAPK14 (0.71) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL1660245 | 0.88 | RAF1 (0.68) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL12500709 | 0.88 | RAF1 (0.67) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL1660255 | 0.88 | RAF1 (0.79) | RAF1KDREPHX2RETMAPK14 | |
| SCHEMBL14453671 | 0.88 | RAF1 (0.63) | RAF1KDREPHX2RETMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | claimed |
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |