Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 15/20 | 0.70 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.54 |
| ▸ | TTBK2 | Q6IQ55 | 2/20 | 0.54 |
| ▸ | CDC7 | O00311 | 4/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16610300 | 0.86 | TTBK1 (0.67) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610252 | 0.84 | TTBK1 (0.70) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610295 | 0.84 | TTBK1 (0.70) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610209 | 0.84 | TTBK1 (0.65) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610206 | 0.84 | TTBK1 (0.65) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610307 | 0.83 | TTBK1 (0.69) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610299 | 0.83 | TTBK1 (0.68) | TTBK1MAP3K14TTBK2PAK4PIKFYVE | |
| SCHEMBL16610302 | 0.83 | TTBK1 (0.68) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL16610218 | 0.82 | TTBK1 (0.67) | TTBK1MAP3K14TTBK2CDC7PAK4 | |
| SCHEMBL20307323 | 0.82 | TTBK1 (0.67) | TTBK1MAP3K14TTBK2CDC7PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3071566-B1 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-C]PYRIDINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-15 | — | — | EP | disclosed |
| US-10005773-B2 | 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-26 | — | — | US | disclosed |
| US-10005773-B2 | 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-26 | — | — | US | disclosed |
| US-20160257679-A1 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2016-09-08 | — | — | US | disclosed |
| US-20160257679-A1 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS | ARGENTA DISCOVERY 2009 LIMITED (GB) | 2016-09-08 | — | — | US | disclosed |
| WO-2015044267-A1 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-04-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10005773-B2 | 1-(4-pyrimidinyl)-1H-pyrrolo[3,2-c]pyridine derivatives as NIK inhibitors | MAP3K14, MAP3K15, MAP3K12 | TTBK1 578/4885MAP3K14 1/4885TTBK2 1063/4885 |
| US-20160257679-A1 | NEW 1-(4-PYRIMIDINYL)-1H-PYRROLO[3,2-c]PYRIDINE DERIVATIVES AS NIK INHIBITORS | MAP3K14, MAP3K15, MAP3K12 | TTBK1 558/4885MAP3K14 1/4885TTBK2 1009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.