Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.71 |
| ▸ | FLT3 | P36888 | 18/20 | 0.71 |
| ▸ | KIT | P10721 | 16/20 | 0.71 |
| ▸ | CSF1R | P07333 | 8/20 | 0.65 |
| ▸ | FLT4 | P35916 | 8/20 | 0.65 |
| ▸ | FLT1 | P17948 | 7/20 | 0.65 |
| ▸ | LYN | P07948 | 6/20 | 0.65 |
| ▸ | PLK4 | O00444 | 5/20 | 0.65 |
| ▸ | AURKA | O14965 | 5/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.65 |
| ▸ | MET | P08581 | 5/20 | 0.65 |
| ▸ | PRKACA | P17612 | 5/20 | 0.65 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.65 |
| ▸ | STK3 | Q13188 | 5/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.65 |
| ▸ | MARK2 | Q7KZI7 | 5/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.65 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.65 |
| ▸ | SRC | P12931 | 5/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1659200 | 0.89 | KDR (0.71) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL1660410 | 0.89 | KDR (0.68) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL1660311 | 0.88 | KDR (0.78) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL1662335 | 0.87 | KDR (0.81) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL2239738 | 0.85 | KDR (0.53) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL421753 | 0.83 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL419770 | 0.82 | KDR (0.74) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL422630 | 0.81 | KDR (0.81) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL423819 | 0.79 | KDR (0.82) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL421644 | 0.79 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046991-A2 | CERTAIN SUBSTITUTED UREAS AS MODULATORS OF KINASE ACTIVITY | GILEAD CONNECTICUT, INC. (US) | 2011-04-21 | — | — | WO | disclosed |