Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12479658 | 0.91 | HTR2C (0.54) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12478591 | 0.85 | HCRTR2 (0.49) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12479669 | 0.85 | HTR2A (0.48) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12479715 | 0.84 | HTR2A (0.52) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12479594 | 0.83 | HCRTR2 (0.50) | MEN1KMT2AHCRTR2HCRTR1MAPT | |
| SCHEMBL12480073 | 0.82 | HTR2A (0.47) | HTR2CMEN1KMT2AHCRTR2HTR2A | |
| SCHEMBL12479690 | 0.81 | HCRTR2 (0.49) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12479655 | 0.81 | HCRTR2 (0.49) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12479365 | 0.80 | HCRTR2 (0.49) | HTR2CMEN1KMT2AHCRTR2HCRTR1 | |
| SCHEMBL12479753 | 0.79 | CDK4 (0.59) | HTR2CKMT2AHCRTR2HCRTR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675801-B1 | NOVEL PYRAZOLE AND IMIDAZOLE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-04-08 | — | — | EP | disclosed |