Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.73 |
| ▸ | MTOR | P42345 | 5/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.63 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.63 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.63 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.57 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.52 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612969 | 0.89 | PIK3CA (0.75) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16612760 | 0.85 | PIK3CA (0.72) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL167274 | 0.84 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16613052 | 0.83 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL168252 | 0.82 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16613081 | 0.80 | PIK3CA (0.71) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL16613066 | 0.78 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL114249 | 0.78 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL114941 | 0.78 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL163693 | 0.77 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | claimed |