Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 8/20 | 1.00 |
| ▸ | PIK3R1 | P27986 | 8/20 | 1.00 |
| ▸ | PIK3CB | P42338 | 8/20 | 1.00 |
| ▸ | PIK3CG | P48736 | 8/20 | 1.00 |
| ▸ | MTOR | P42345 | 5/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL116429 | 1.00 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL114403 | 1.00 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL114402 | 1.00 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL166238 | 1.00 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL167711 | 0.91 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL167712 | 0.91 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL116769 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL116768 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL168921 | 0.90 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL168889 | 0.89 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | disclosed |