Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.63 |
| ▸ | MTOR | P42345 | 10/20 | 0.63 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16612780 | 0.88 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL16612918 | 0.79 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL16613020 | 0.79 | PIK3CA (0.61) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL167337 | 0.78 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL167338 | 0.78 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL163063 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL163062 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL165621 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL115448 | 0.76 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3R1PIK3CB | |
| SCHEMBL7774680 | 0.75 | PIK3CA (0.86) | PIK3CAMTORPIK3CDPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | claimed |