Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.62 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.62 |
| ▸ | MTOR | P42345 | 5/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.61 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16613072 | 0.89 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL16613082 | 0.88 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL16613081 | 0.85 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL3116122 | 0.82 | PIK3CA (0.81) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL16612969 | 0.82 | PIK3CA (0.75) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL168343 | 0.81 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL16613066 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL16613054 | 0.79 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL168285 | 0.77 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL16613052 | 0.75 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424859-B1 | INHIBITORS OF PI3 KINASE AND / OR MTOR | AMGEN INC (US) | 2015-04-08 | — | — | EP | claimed |