Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1661510 | 0.87 | DYRK1A (0.40) | SCN9A | |
| SCHEMBL1660621 | 0.85 | DYRK1A (0.36) | SCN9A | |
| SCHEMBL14727667 | 0.84 | LRRK2 (0.36) | — | |
| SCHEMBL14717156 | 0.77 | SCN9A (0.37) | SCN9A | |
| SCHEMBL1660820 | 0.77 | SCN9A (0.37) | SCN9A | |
| SCHEMBL14718522 | 0.76 | SCN9A (0.37) | SCN9A | |
| SCHEMBL14727724 | 0.76 | SCN9A (0.39) | SCN9A | |
| SCHEMBL6903438 | 0.75 | SCN9A (0.38) | SCN9A | |
| SCHEMBL14727933 | 0.75 | SCN9A (0.38) | SCN9A | |
| SCHEMBL6902712 | 0.75 | SCN9A (0.36) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488031-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011046774-A1 | DIARYL ETHER DERIVATIVES AS NOTCH SPARING GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-04-21 | — | — | WO | disclosed |