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SCHEMBL16615939

SCHEMBL16615939

Cc1ncc(CNC(=O)c2cnc(CNC(=O)c3cccc(F)c3)cn2)s1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GRIN2A Q12879 3/20 0.58
▸ GRIN1 Q05586 2/20 0.58
▸ HPGD P15428 2/20 0.47
▸ GRIN2B Q13224 1/20 0.46
▸ ALDH1A1 P00352 3/20 0.44
▸ GAA P10253 2/20 0.44
▸ TSHR P16473 2/20 0.44
▸ MEN1 O00255 2/20 0.44
▸ KMT2A Q03164 2/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ ROCK2 O75116 2/20 0.41
▸ CYP1A2 P05177 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ TP53 P04637 2/20 0.39
▸ LMNA P02545 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ SLC8A1 P32418 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ NPY1R P25929 1/20 0.39
▸ RECQL P46063 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16615944 0.89 GRIN2A (0.59) GRIN2AGRIN1GRIN2B
SCHEMBL16615937 0.88 GRIN2A (0.61) GRIN2AGRIN1HPGDGRIN2BALDH1A1
SCHEMBL16615798 0.87 HPGD (0.47) GRIN2AGRIN1HPGDGRIN2BALDH1A1
SCHEMBL16615938 0.85 GRIN2A (0.51) GRIN2AGRIN1GRIN2BALDH1A1GAA
SCHEMBL16615814 0.82 GRIN2A (0.61) GRIN2AGRIN1HPGDGRIN2BALDH1A1
SCHEMBL16713100 0.81 GRIN2A (0.50) GRIN2AGRIN1GRIN2BALDH1A1
SCHEMBL16598153 0.79 GRIN2A (0.67) GRIN2AGRIN1HPGDGRIN2BALDH1A1
SCHEMBL16598210 0.78 GRIN2A (0.74) GRIN2AGRIN1GRIN2BALDH1A1KMT2A
SCHEMBL16615933 0.78 GRIN2A (0.77) GRIN2AGRIN1GRIN2BALDH1A1MEN1
SCHEMBL16597898 0.78 GRIN2A (0.55) GRIN2AGRIN1HPGDGRIN2BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9963434-B2 N-arylmethyl sulfonamide negative modulators of NR2A LUC THERAPEUTICS, INC. (US) 2018-05-08 — — US disclosed
US-9963434-B2 N-arylmethyl sulfonamide negative modulators of NR2A LUC THERAPEUTICS, INC. (US) 2018-05-08 — — US disclosed
US-20160311782-A1 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A NOVARTIS AG (CH) 2016-10-27 — — US disclosed
US-20160311782-A1 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A NOVARTIS AG (CH) 2016-10-27 — — US disclosed
US-20150141433-A1 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A MNEMOSYNE PHARMACEUTICALS, INC. 2015-05-21 — — US disclosed
US-20150141433-A1 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A MNEMOSYNE PHARMACEUTICALS, INC. 2015-05-21 — — US disclosed
WO-2015048503-A2 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A MNEMOSYNE PHARMACEUTICALS, INC. (US) 2015-04-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160311782-A1 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A GRIN2A, GRIN2B, NR2C2 GRIN2A 1/4885GRIN1 5/4885HPGD 3080/4885
US-20150141433-A1 N-ARYLMETHYL SULFONAMIDE NEGATIVE MODULATORS OF NR2A GRIN2A, GRIN2B, NR2C2 GRIN2A 1/4885GRIN1 5/4885HPGD 3080/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.