⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL910577 | 1.00 | — | — | |
| SCHEMBL1661174 | 1.00 | — | — | |
| Cysteine SCHEMBL27530294 | 0.77 | — | — | |
| SCHEMBL27228697 | 0.77 | — | — | |
| SCHEMBL27949640 | 0.77 | — | — | |
| SCHEMBL27228679 | 0.77 | — | — | |
| Cysteine SCHEMBL1819437 | 0.77 | PTGS1 (0.89) | — | |
| Cysteine SCHEMBL1819440 | 0.77 | PTGS1 (0.89) | — | |
| SCHEMBL6291929 | 0.77 | — | — | |
| Cysteine SCHEMBL5831493 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110872314-A | Asymmetric silicon-based substituted rhodamine derivative, and preparation method and application thereof | 华东师范大学 | 2020-03-10 | — | — | CN | claimed |
| US-20150323542-A1 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-11-12 | — | — | US | claimed |
| US-20150322107-A1 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS | CAYMAN CHEMICAL COMPANY, INCORPORATED | 2015-11-12 | — | — | US | claimed |
| US-9120820-B2 | Fluorescent molecular probes for use in assays that measure test compound competitive binding with SAM-utilizing proteins | CAYMAN CHEMICAL COMPANY, INCORPORATED (US) | 2015-09-01 | — | — | US | claimed |
| US-20120295283-A1 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-11-22 | — | — | US | claimed |
| WO-2012159072-A2 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS | CAYMAN CHEMICAL COMPANY, INCORPORATED (US) | 2012-11-22 | — | — | WO | claimed |
| CN-110872314-A | Asymmetric silicon-based substituted rhodamine derivative, and preparation method and application thereof | 华东师范大学 | 2020-03-10 | — | — | CN | disclosed |
| CN-110872314-A | Asymmetric silicon-based substituted rhodamine derivative, and preparation method and application thereof | 华东师范大学 | 2020-03-10 | — | — | CN | disclosed |
| US-20150323542-A1 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2015-11-12 | — | — | US | disclosed |
| US-20150322107-A1 | FLUORESCENT MOLECULAR PROBES FOR USE IN ASSAYS THAT MEASURE TEST COMPOUND COMPETITIVE BINDING WITH SAM-UTILIZING PROTEINS | CAYMAN CHEMICAL COMPANY, INCORPORATED | 2015-11-12 | — | — | US | disclosed |
| US-9120820-B2 | Fluorescent molecular probes for use in assays that measure test compound competitive binding with SAM-utilizing proteins | CAYMAN CHEMICAL COMPANY, INCORPORATED (US) | 2015-09-01 | — | — | US | disclosed |
| CN-103619817-A | Novel bicyclic nitrogen containing heteroaryl TGR5 receptor modulators | BRISTOL MYERS SQUIBB CO | 2014-03-05 | — | — | CN | disclosed |
| EP-2306994-B1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC (US) | 2013-08-14 | — | — | EP | disclosed |
| US-7842685-B2 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-11-30 | — | — | US | disclosed |
| CN-101878216-A | Pyrimidine derivatives as protein kinase inhibitors | CYCLACEL LTD | 2010-11-03 | — | — | CN | disclosed |
| US-20100029611-A1 | S1P1 receptor agonists and use thereof | AMGEN INC. (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2009154775-A1 | S1P1 RECEPTOR AGONISTS AND USE THEREOF | AMGEN INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| CN-1330638-C | Substituted imidazolidine derivatives, their prepn., their use and pharmaceutical prepn. comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 2007-08-08 | — | — | CN | disclosed |
| CN-1407982-A | Serotonergic benzofurans | LILLY CO ELI (US) | 2003-04-02 | — | — | CN | disclosed |
| CN-1225360-A | Substituted imidazolidine derivatives, their prepn., their use and pharmaceutical prepn. comprising them | HOECHST MARION ROUSSEL DE GMBH (DE) | 1999-08-11 | — | — | CN | disclosed |